Cancer BiologybioRxivPreprint
Exploiting a PAX3-FOXO1-induced synthetic lethal ATR dependency for rhabdomyosarcoma therapy
H. Dorado Garcia, Y. Bei, J. von Stebut…·A. G. Henssen
This study identifies ATR as a synthetic lethal target in PAX3-FOXO1-driven rhabdomyosarcoma, showing ATR inhibition enhances PARP inhibitor efficacy and is tolerated in patients.
DOI 10.1101/2020.12.04.411413