Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses
J. Lee, J. Zhang, Y.-J. Chung, J. H. Kim, C. M. Kook, J. M. Gonzalez-Navajas, D. S. Herdman, B. Nürnberg, P. Insel, M. Corr, A. Tao, K. Yasuda, I. R. Rifkin, D. H. Broide, R. Sciammas, , E. Raz
The paper shows that cAMP-PKA-CREB signaling in cDC2s represses IRF4 and KLF4, promoting Th17 responses and inhibiting Th2, with similar effects observed through PRR-dependent signals like curdlan.
bioRxiv · Jun 28, 2019Immunology