Author

P. J. Roach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

A. D. Cherrington· 1 shared A. DePaoli-Roach· 1 shared A. Uittenbogaard· 1 shared B. Farmer· 1 shared B. L. Hodges· 1 shared C. J. Ramnanan· 1 shared D. Armstrong· 1 shared D. M. Segvich· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperPhysiology

A. D. Cherrington

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Author profile →

2 papers

Recent·Most cited

Integration of metabolic flux with hepatic glucagon signaling and gene expression profiles in the conscious dog

K. C. Coate, C. J. Ramnanan, M. Smith, J. J. Winnick, G. Kraft, J. M. Irimia, B. Farmer, P. Donahue, P. J. Roach, A. D. Cherrington, D. S. Edgerton

This study examines how glucagon affects hepatic glucose production and gene expression in conscious dogs over time, revealing transient metabolic flux changes and gene regulation patterns.

bioRxiv · Sep 28, 2023Physiology

Targeting pathogenic Lafora bodies in Lafora disease using an antibody-enzyme fusion

M. K. Brewer, A. Uittenbogaard, G. L. Austin, J. J. McCarthy, D. M. Segvich, A. DePaoli-Roach, P. J. Roach, B. L. Hodges, J. Zeller, J. R. Pauly, T. McKnight, D. Armstrong, M. Gentry

This paper develops an antibody-enzyme fusion that degrades Lafora bodies in a mouse model of Lafora disease, reducing LB load and showing therapeutic potential.

bioRxiv · Jun 21, 2019Biochemistry