MCU gain- and loss-of-function models define the duality of mitochondrial calcium uptake in heart failure
J. F. Garbincius, T. S. Luongo, J. P. Lambert, A. S. Mangold, E. K. Murray, A. N. Hildebrand, P. Jadiya, J. W. Elrod
This study uses gain- and loss-of-function models of the mitochondrial calcium uniporter to show that mCa2+ uptake is essential for early cardiac contractility but harmful under sustained stress.
bioRxiv · Apr 17, 2023 · PreprintPhysiology