Pharmacologic Activation of Integrated Stress Response Kinases Inhibits Pathologic Mitochondrial Fragmentation
K. R. Baron, S. Oviedo, S. Krasny, M. Zaman, R. Aldakhlallah, P. Bora, P. Mathur, G. Pfeffer, M. J. Bollong, T. Shutt, D. Grotjahn, L. Wiseman
This study shows that pharmacologic activation of ISR kinases HRI or GCN2 prevents mitochondrial fragmentation in disease models.
bioRxiv · Jun 10, 2024Cell Biology