B. Goud

Phase partitioning rules Rab domain formation, growth and identity

The paper investigates how LLPS properties of Rab partners influence Rab domain formation, growth, and identity, showing their role in regulating endocytic vesicle tethering and fusion.

The recycling endosome biogenesis machinery coordinates BACE1 endosomal sorting and amyloid-Beta production

This study identifies the recycling endosome biogenesis machinery as critical for BACE1 endosomal sorting and amyloid-beta production in Alzheimer's disease.

A phosphorylation switch regulates RAB6 function during mitosis

This study identifies that phosphorylation of RAB6 by Plk1 during mitosis regulates its function and localization, affecting cell division processes.

Biogenesis of specialized lysosomes in differentiated keratinocytes relies on close apposition with the Golgi apparatus

This study identifies a novel mechanism where Golgi-lysosome contact in differentiated keratinocytes supports specialized lysosome function and protein secretion.

Membrane tension spatially organizes lysosomal exocytosis

This study shows that lysosomal exocytosis clusters spatially at the plasma membrane of RPE1 cells, driven by membrane tension patterns controlled by focal adhesions.

BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation

This study shows BIN1 is required for filopodia formation by bundling actin and recruiting dynamin and ezrin, dependent on IRSp53 and membrane curvature.

Regulation of neuronal progenitor delamination by dynein-driven post-Golgi apical transport

This study identifies a RAB6-dynein-LIS1 complex that regulates apical transport in radial glial cells, essential for maintaining neuroepithelial integrity and proper brain development.

A new approach to measure forces at junction vertices in an epithelium

This study introduces a method combining laser ablation and intracellular microrheology to measure tensile forces at cell-cell junctions and demonstrates mechanical asymmetry induced by aPKCi overexpression.

A comprehensive library of fluorescent constructs of SARS-CoV-2 proteins and their initial characterization in different cell types

The paper presents a library of fluorescent SARS-CoV-2 protein constructs and their initial characterization in human cell lines and yeast.

Intracellular stiffening competes with cortical softening in glioblastoma cells

This study shows that glioblastoma cells are softer globally but stiffer intracellularly, suggesting mechanical phenotyping could be useful for diagnosis.

Transcription Factor EB regulates phosphatidylinositol-3-phosphate levels on endomembranes and alters lysosome positioning in the bladder cancer model

This study identifies TFEB's role in regulating PtdIns3P levels and lysosome positioning in bladder cancer, suggesting it as a potential biomarker and therapeutic target.

Role of a kinesin motor in cancer cell mechanics

This study investigates the role of KIF20A, a kinesin motor protein, in bladder cancer cell mechanics and motility, showing that its inhibition alters intracellular and cortical stiffness.

Two polybasic domains of septin9 control septin filaments assembly and Golgi integrity

This study identifies two polybasic domains in septin 9 that mediate interaction with phosphoinositides and are critical for septin filament assembly and Golgi integrity.

Feedback between membrane tension, lipid shape and curvature in the formation of packing defects

The paper investigates how membrane tension, lipid shape, and curvature interact to influence lipid packing defects and membrane deformation through ALPS binding and conical lipid effects.

RAB6 and microtubules restrict secretion to focal adhesions

The paper shows that RAB6 and microtubules direct secretion to focal adhesions by restricting exocytosis to localized hotspots.