Combating viral contaminants in CHO cells by engineering STAT1 mediated innate immunity
A. W. T. Chiang, S. Li, B. P. Kellman, G. Chattopadhyay, Y. Zhang, C.-C. Kuo, J. M. Gutierrez, F. Ghazi, H. Schmeisser, P. Menard, S. Petersen Bjorn, B. G. Voldborg, A. S. Rosenberg, M. Puig, N. E. Lewis
The paper identifies Gfi1 and Trim24 as repressors of STAT1 in CHO cells and shows that knocking them out increases resistance to RNA viruses.
bioRxiv · Sep 21, 2018Bioengineering