N. E. Lewis

This paper develops a combined systems antigenomics-serology workflow to characterize circulating IgG against Group A Streptococcus, revealing antigen repertoire and functional properties of antibodies in healthy and infected individuals.

The paper identifies hyperosmotic stress-responsive genes in CHO cells using CRISPR/Cas9 screening and validates their role in stress resistance and protein production.

This study identifies vascular proteome changes preceding organ dysfunction in sepsis using a murine model and integrative analysis.

This study shows that 3-sialyllactose reduces inflammation and atherosclerosis in mice by modulating transcriptional activity in macrophages.

The paper defines housekeeping genes using experimental data and identifies conserved gene lists across multiple species.

This study restores DNA repair genes in CHO cells, improving genome stability and protein titer.

This study shows that commensal bacteria modify heparan sulfate, reducing SARS-CoV-2 spike protein binding and that this bacterial presence decreases with age, increasing COVID-19 susceptibility.

The paper characterizes glycosylation of SARS-CoV-2 Spike and ACE2 using glycomics and simulations to understand their interactions and guide immunogen design.

The paper uses a CRISPR-Cas9 screen in Chinese hamster ovary cells to identify glutamine-sensitive genes, revealing a novel lipase involved in TCA cycle regulation.

The paper identifies Gfi1 and Trim24 as repressors of STAT1 in CHO cells and shows that knocking them out increases resistance to RNA viruses.