Author

P. Mestdagh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Physiology· 1

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Organism:human· 5 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

J. Vandesompele· 4 shared J. Anckaert· 3 shared N. Yigit· 3 shared B. De Paepe· 2 shared F. Speleman· 2 shared K. De Preter· 2 shared K. Vanderheyden· 2 shared L. Delhaye· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersCancer Biology

J. Vandesompele

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Author profile →

5 papers

Recent·Most cited

Human skeletal muscle fiber heterogeneity beyond myosin heavy chains

R. Moreno-Justicia, T. Van der Stede, B. Stocks, J. Laitila, R. A. Seaborne, A. Van de Loock, E. Lievens, D. Samodova, L. Marin-Arraiza, O. Dmytriyeva, R. Browaeys, K. Van Vossel, L. Moesgaard, N. Yigit, J. Anckaert, , A. S. Deshmukh

This study identifies sources of skeletal muscle fiber heterogeneity beyond myosin heavy chains using transcriptomic and proteomic data from human muscle fibers.

bioRxiv · Sep 7, 2023Physiology

mTOR inhibition enhances delivery and activity of antisense oligonucleotides in uveal melanoma cells

S. Dewaele, L. Delhaye, B. De Paepe, B. Bogaert, R. Martinez, J. Anckaert, N. Yigit, J. Nuytens, R. Van Coster, S. Eyckerman, K. Raemdonck, P. Mestdagh

This study shows that mTOR inhibition improves the delivery and effectiveness of antisense oligonucleotides in uveal melanoma cells and other cell types.

bioRxiv · Sep 29, 2021Cancer Biology

The long non-coding RNA SAMMSON is essential for uveal melanoma cell survival

S. Dewaele, L. Delhaye, B. De Paepe, E. De Bony, J. De Wilde, K. Vanderheyden, J. Anckaert, N. Yigit, E. VandenEynde, F. Nemati, D. Decaudin, A. Jochemsen, E. Leucci, J. Vandesompele, J. Van Dorpe, , P. Mestdagh

This study shows that inhibiting the lncRNA SAMMSON reduces uveal melanoma cell growth and viability by impairing mitochondrial function and protein translation.

bioRxiv · Jan 18, 2021Cancer Biology

Recurrent chromosomal imbalances provide selective advantage to human embryonic stem cells under enhanced replicative stress conditions

L. M. Mus, S. Van Haver, M. Popovic, W. Trypsteen, S. Lefever, N. Zeltner, Y. Ogando, E. Z. Jacobs, G. Denecker, E. Sanders, C. Van Neste, S. Vanhauwaert, B. Decaesteker, D. Deforce, F. Van Nieuwerburgh, , F. Speleman

This study shows that chromosomal imbalances in hESCs provide a proliferative advantage under replicative stress, similar to cancer cells.

bioRxiv · Nov 6, 2020Cancer Biology

Circulating microRNA biomarkers for metastatic disease in neuroblastoma patients

F. Zeka, A. Van Goethem, K. Vanderheyden, F. Demuynck, T. Lammens, A. Decock, H. H. Helsmoortel, J. Vermeulen, R. Noguera, A. P. Berbegall, V. Combaret, G. Schleiermacher, G. Laureys, A. Schramm, J. H. Schulte, , J. Vandesompele

This study identifies 9 miRNAs associated with metastatic neuroblastoma by analyzing serum miRNome in patient cohorts and xenografted mice.

bioRxiv · Apr 27, 2018Cancer Biology