MicrobiologybioRxivPreprint
Retrovirus-induced leukemia - hijack of T-cell activation mechanisms revealed by single-cell analysis
B. J. Y. Tan, K. Sugata, O. Reda…·Y. Satou
This study uses single-cell RNA-Seq and TCR-Seq to show HTLV-1-infected T-cells transition into highly activated ATL cells with Treg signatures and upregulated HLA class II, enabling immune evasion.