BiochemistrybioRxivPreprint
A glycerol shunt functions as a glucose excess security valve in pancreatic β-cells
A. Al-Mass, P. Poursharifi, M.-L. Peyot…·M. Prentki
This study identifies a glycerol shunt in pancreatic β-cells that mitigates glucose excess by diverting glucose carbons to glycerol production, thereby preventing insulin hypersecretion and glucotoxicity.
DOI 10.1101/2021.11.20.468884