Quinazoline-quinoline bisubstrate inhibitors target eukaryotic translation initiation factor 3 in Plasmodium falciparum
I. Dobrescu, E. Hammam, J. M. Dziekan, A. Claës, L. Halby, P. Preiser, Z. Bozdech, P. B. Arimondo, A. Scherf, F. Nardella
This study identifies PfEIF3i as a target of quinoline-quinazoline inhibitors in Plasmodium falciparum, showing its essential role in parasite development and potential as an antimalarial drug target.
bioRxiv · Dec 10, 2022 · PreprintPharmacology & Toxicology