Author

S. K. Lai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Microbiology· 2 Cell Biology· 1 Immunology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 3 Organism:plant (other)· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Schaefer· 2 shared H. Y. Li· 2 shared A. Chen· 1 shared A. J. Hickey· 1 shared A. Kam· 1 shared A. P. C. Lim· 1 shared A. R. Fernie· 1 shared B. Bratcher· 1 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersBioengineering

A. Schaefer

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Erythrocyte signalling is critical for Plasmodium falciparum invasion

J. J. M. Yong, X. Gao, P. Prakash, S. K. Lai, M. W. Chen, J. J. L. Neo, J. Lescar, H. Y. Li, P. R. Preiser

This study shows that Plasmodium falciparum merozoite invasion depends on host cAMP-Ca2+ signalling, with RH5-Basigin interaction triggering cAMP rise and Ca2+ influx.

bioRxiv · Jul 18, 2022 · PreprintMicrobiology

Genomic, transcriptomic, and metabolomic analysis of Traditional Chinese Medicine plant Oldenlandia corymbosa reveals the biosynthesis and mode of action of anti-cancer metabolites

I. Julca, D. Mutwil-Anderwald, V. Manoj, Z. Khan, S. K. Lai, L. K. Yang, I. T. Beh, J. Dziekan, Y. P. Lim, S. K. Lim, Y. W. Low, Y. I. Lam, Y. Mu, Q. W. Tan, P. Nuc, , M. Mutwil

This study identifies ursolic acid as the main anti-cancer compound in Oldenlandia corymbosa and reveals its mode of action through genomic, transcriptomic, and metabolomic analysis.

bioRxiv · Jun 14, 2022 · PreprintPlant Biology

Stable nebulization and muco-trapping properties of Regdanvimab/IN-006 support its development as a potent, dose-saving inhaled therapy for COVID-19

M. D. McSweeney, I. Stewart, Z. Richardson, H. Kang, Y. Park, C. Kim, K. Tiruthani, W. Wolf, A. Schaefer, P. Kumar, H. Aurora, J. Hutchins, J. M. Cho, A. J. Hickey, S. Y. Lee, S. K. Lai

This paper demonstrates that IN-006, a reformulated Regdanvimab, effectively traps SARS-CoV-2 virus-like particles in human airway mucus and achieves higher lung concentrations in rats when nebulized compared to intravenous delivery.

bioRxiv · Feb 27, 2022Bioengineering

Modeling predicts mechanisms altered by mutations of the SARS-CoV-2 delta and omicron variants

J. Pearson, T. Wessler, A. Chen, R. C. Boucher, R. Freeman, S. K. Lai, R. Pickles, M. G. Forest

The paper models how mutations in SARS-CoV-2 delta and omicron variants alter viral load and infection outcomes by simulating different mechanistic changes.

bioRxiv · Feb 23, 2022 · PreprintImmunology

The cellular characterisation of SARS-CoV-2 spike protein in virus-infected cells using Receptor Binding Domain-binding specific human monoclonal antibodies.

C. E.-Z. Chan, C.-G. Ng, A. P. C. Lim, S. G.-K. Seah, D. H. Chye, S. K. K. Wong, J.-H. Lim, V. Z.-Y. Lim, S. K. Lai, P.-S. Wong, K.-M. Leong, Y. Liu, R. Sugrue, B. H. Tan

This paper uses monoclonal antibodies to study the conformation and localization of the SARS-CoV-2 spike protein's receptor-binding domain in infected cells, revealing its presence in the Golgi complex and its role in cell-to-cell transmission.

bioRxiv · Dec 6, 2021 · PreprintMicrobiology

Hexavalent Sperm-Binding IgG Antibody Released from Self-Dissolving Vaginal Film Enables Potent, On-Demand Non-Hormonal Female Contraception

B. Shrestha, K. Vincent, A. Schaefer, Y. Zhu, G. Vargas, M. Motamedi, K. Swope, J. Morton, C. Simpson, H. Pham, M. B. Brennan, M. H. Pauly, L. Zeitlin, B. Bratcher, K. J. Whaley, , S. K. Lai

This paper develops a non-hormonal contraceptive method using a hexavalent sperm-binding antibody delivered via a dissolving vaginal film, showing potent sperm inhibition in sheep.

bioRxiv · Apr 19, 2021 · PreprintBioengineering

Plasmodium falciparum Replication factor C subunit 1 is involved in genotoxic stress response

O. Sheriff, Y. Aniweh, S. K. Lai, H. L. Loo, S. K. Sze, P. Preiser

This study investigates the role of PfRFC1 in the genotoxic stress response of Plasmodium falciparum, showing its involvement in DNA replication, repair, and programmed cell death.

bioRxiv · May 26, 2020Cell Biology