METTL3/MYCN cooperation drives neural crest differentiation and provides therapeutic vulnerability in neuroblastoma
K. Thombare, R. Vaid, P. Pucci, A. Mendez, R. Burgos-Panadero, R. Ayyalusamy, A. A. Rehan, M. H. Baig, S. D. Nale, C. Bartenhagen, J. j. Dong, M. Fischer, S. D. Turner, T. Mondal
This study shows METTL3 and MYCN cooperate to maintain undifferentiated neural crest cells in neuroblastoma, and METTL3 inhibition promotes differentiation and chemosensitivity.
bioRxiv · Oct 6, 2023Cancer Biology