Author

A. Luini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 7 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell signaling & trafficking· 6 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

R. Rizzo· 4 shared S. Parashuraman· 4 shared D. Russo· 3 shared G. D'Angelo· 3 shared M. Lo Monte· 3 shared P. Henklein· 3 shared I. Agliarulo· 2 shared L. Capolupo· 2 shared

Activity by Year

2016-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersCell Biology

R. Rizzo

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The Golgi checkpoint: Golgi unlinking during G2 is required for correct spindle formation and cytokinesis

F. Mascanzoni, I. Ayala, R. Iannitti, A. Luini, A. Colanzi

The paper shows that Golgi unlinking during G2 is essential for proper spindle formation and cytokinesis, as disrupting this process leads to mitotic defects and increased cell transformation risk.

bioRxiv · Mar 5, 2023 · PreprintCell Biology

Calcium flux through ER-TGN contact sites facilitates cargo export

B. R. Ramazanov, R. Di Martino, A. Kumar, A. Parchure, Y. Kim, O. Griesbeck, M. A. Schwartz, A. Luini, J. von Blume

The paper shows that Ca2+ flux through ER-TGN contact sites is essential for cargo export via SPCA1 and Cab45, using a FRET sensor to measure real-time Ca2+ flow.

bioRxiv · Dec 19, 2022 · PreprintCell Biology

Prioritization of driver genes in cancer-associated copy number alterations identifies B4GALT5 as a glycooncogene

S. Parashuraman, P. Sahu, F. Russo, I. Agliarulo, R. Rizzo, M. Lo Monte, N. Normanno, S. Soddu, F. Carlomagno, A. Luini

The paper identifies B4GALT5 as a glyco-oncogene by analyzing copy number alterations in glycosylation regulator genes across cancer datasets.

bioRxiv · Mar 30, 2022 · PreprintCancer Biology

Precision localization of cellular proteins with fluorescent Fab-based probes

F. Liccardo, M. Lo Monte, B. Corrado, M. Veneruso, S. Celentano, M. R. Coscia, G. Coppola, P. Pucci, G. Palumbo, A. Luini, M. Lampe, V. M. Marzullo

This study introduces Fluo-N-Fabs, fluorescent reagents that reduce linkage error in super-resolution microscopy by over five-fold compared to conventional methods.

bioRxiv · Oct 18, 2021 · PreprintCell Biology

Autoregulatory circuit regulating basolateral cargo export from the TGN: role of the orphan receptor GPRC5A in PKD signaling and cell polarity.

R. Di Martino, A. Capalbo, L. Sticco, A. Varavallo, V. Kunnathully, V. De Luca, N. R. Iyengar, M. Lo Monte, P. Henklein, J. Cancino, A. Luini

The paper identifies a mechanism called ARTG that regulates basolateral cargo export from the TGN via GPRC5A, PLCβ3, and PKD signaling, and shows its role in epithelial cell polarity.

bioRxiv · May 26, 2020 · PreprintCell Biology

Regulated compartmentalization of enzymes in Golgi by GRASP55 controls cellular glycosphingolipid profile and function

P. Pothukuchi, I. Agliarulo, M. Pirozzi, R. Rizzo, D. Russo, G. Turacchio, J. Nuchel, J.-S. Yang, C. J. C. Gehin, L. Capolupo, M. J. Hernandez-Corbacho, A. Biswas, G. Vanacore, N. Dathan, T. Nitta, , S. Parashuraman

This study identifies GRASP55 as a regulator of enzyme compartmentalization in the Golgi, which controls glycosphingolipid biosynthesis and cellular glycan profiles.

bioRxiv · May 3, 2020 · PreprintCell Biology

The Glyco-enzyme adaptor GOLPH3 Links Intra-Golgi Transport Dynamics to Glycosylation Patterns and Cell Proliferation

R. Rizzo, D. Russo, K. Kurokawa, P. Sahu, B. Lombardi, D. Supino, M. Zhukovsky, A. Vocat, P. Pothukuchi, V. Kunnathully, L. Capolupo, G. Boncompain, C. Vitagliano, F. Zito Marino, G. Aquino, , A. Luini

This study shows GOLPH3 regulates glycosylation and cell proliferation by controlling glyco-enzyme recycling and lysosomal degradation.

bioRxiv · Dec 23, 2019 · PreprintCell Biology

Sphingolipid metabolic flow controls phosphoinositide turnover at thetrans Golgi network

S. Capasso, L. Sticco, R. Rizzo, M. Pirozzi, D. Russo, N. Dathan, F. Campelo, J. van Galen, A. Hausser, V. Malhotra, S. Parashuraman, A. Luini, G. D'Angelo

The paper identifies a homeostatic circuit that regulates sphingolipid levels at the trans Golgi network by linking sphingomyelin production to PtdIns(4)P dephosphorylation, which interrupts cholesterol and sphingolipid transport.

bioRxiv · Nov 28, 2016Cell Biology