BiophysicsbioRxivPreprint
Perphenazine-macrocycle conjugates rapidly sequester the Aβ42 monomer and inhibit amyloid formation
S. R. Ball, J. S. Adamson, M. A. Sullivan…·M. Sunde
This study designs perphenazine-cyclam conjugates that bind Aβ42 monomers, reducing toxic oligomers and fibrils, and inhibit amyloid formation even with pre-formed seeds.
DOI 10.1101/2020.11.16.384248