Author

M. Kassiou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:electrophysiology· 2 Organism:human· 2 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

M. Connor· 2 shared M. Longworth· 2 shared S. Banister· 2 shared A. H. Kwan· 1 shared A. Makriyannis· 1 shared C. Bladen· 1 shared E. L. Werry· 1 shared F. Jiang· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersPharmacology & Toxicology

M. Connor

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3 papers

Recent·Most cited

Perphenazine-macrocycle conjugates rapidly sequester the Aβ42 monomer and inhibit amyloid formation

S. R. Ball, J. S. Adamson, M. A. Sullivan, M. R. Zimmermann, V. Lo, M. Sanz-Hernandez, F. Jiang, A. H. Kwan, E. L. Werry, T. P. Knowles, M. Kassiou, G. Meisl, M. H. Todd, P. R. Rutledge, M. Sunde

This study designs perphenazine-cyclam conjugates that bind Aβ42 monomers, reducing toxic oligomers and fibrils, and inhibit amyloid formation even with pre-formed seeds.

bioRxiv · Nov 16, 2020 · PreprintBiophysics

Modulation of Human T-type Calcium Channels by Synthetic Cannabinoid Receptor Agonists in vitro

C. Bladen, S. Mirlohi, M. Santiago, M. Longworth, M. Kassiou, S. Banister, M. Connor

This study investigates how synthetic cannabinoid receptor agonists modulate human T-type calcium channels, finding potent inhibition and suggesting a potential mechanism for their toxicity.

bioRxiv · Jul 22, 2020Pharmacology & Toxicology

In vitro determination of the CB1 efficacy of illicit synthetic cannabinoids

S. Sachdev, K. Vemuri, S. Banister, M. Longworth, M. Kassiou, M. J. Santiago, A. Makriyannis, M. Connor

This study evaluates the efficacy of 13 synthetic cannabinoids at the CB1 receptor using receptor depletion and operational model fitting, finding most have higher efficacy than Δ9-THC.

bioRxiv · Aug 6, 2018Pharmacology & Toxicology