P. Russell

PD-L1 expression in 522 selected sarcomas with subset analysis of recurrent or metastatic matched samples and association with tumour-infiltrating lymphocytes

This study evaluates PD-L1 expression in 522 sarcomas, finding variability across subtypes and demonstrating increased PD-L1 in some metastatic/recurrent samples, suggesting potential for immune checkpoint inhibitor therapy.

Radtools: R utilities for smooth navigation of medical image data

Radtools simplifies extraction and navigation of metadata from medical image files like DICOM and NIfTI in R.

Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in polynucleotide kinase/phosphatase mutant of fission yeast

This paper shows that in fission yeast lacking PNKP, lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks through alternative pathways.

Sequential interactions with Mre11-Rad50-Nbs1 activate ATM/Tel1 at DNA double-strand breaks and telomeres

This study shows that Tel1 activation at DNA breaks and telomeres occurs through sequential interactions with the MRN complex, requiring Nbs1 for high-affinity binding and Mre11-Rad50 for low-affinity activation.

Multi-BRCT domain protein Brc1 links Rhp18/Rad18 and γH2A to maintain genome stability during S-phase

This study identifies Brc1 as a scaffold protein linking γH2A and Rhp18/Rad18 to maintain genome stability during S-phase in fission yeast.