O. Limbo

HIV skews the SARS-CoV-2 B cell response toward an extrafollicular maturation pathway

This study shows that HIV infection shifts the SARS-CoV-2 B cell response toward an extrafollicular pathway, leading to lower affinity antibodies and reduced vaccine efficacy in people living with HIV.

Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause severe disease

The paper identifies broadly neutralizing antibodies targeting the S2 region of betacoronavirus spikes that protect against SARS-CoV-1, SARS-CoV-2, and MERS-CoV.

Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape

This study engineers SARS-CoV-2 neutralizing antibodies through directed evolution to enhance their potency and reduce viral escape.

Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus

This study identifies nAbs against SIVmac239, reveals structural features of its Env trimer, and shows passive transfer of nAbs protects macaques from infection.

Broadening a SARS-CoV-1 neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution

This paper describes engineering a SARS-CoV-1 neutralizing antibody to effectively neutralize SARS-CoV-2 through directed evolution and affinity maturation.

Rapid isolation of potent SARS-CoV-2 neutralizing antibodies and protection in a small animal model

This study rapidly identifies potent SARS-CoV-2 neutralizing antibodies and demonstrates their protective efficacy in an animal model.

Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in polynucleotide kinase/phosphatase mutant of fission yeast

This paper shows that in fission yeast lacking PNKP, lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks through alternative pathways.

Sequential interactions with Mre11-Rad50-Nbs1 activate ATM/Tel1 at DNA double-strand breaks and telomeres

This study shows that Tel1 activation at DNA breaks and telomeres occurs through sequential interactions with the MRN complex, requiring Nbs1 for high-affinity binding and Mre11-Rad50 for low-affinity activation.