Author

P. Setlow

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 6 Research Focus:cell type annotation· 6 Approach:experimental assay· 5 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 2 Assay:fluorescence / live-cell microscopy· 2 Approach:microscopy & imaging analysis· 2 Assay:metabolomics· 1

Frequent Co-Authors

S. Brul· 7 shared G. Kramer· 3 shared N. O. E. Vischer· 3 shared W. Roseboom· 3 shared J. Wen· 2 shared Y. Huang· 2 shared Z. Tu· 2 shared A. Bogian· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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7 shared papersMicrobiology

S. Brul

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

GerAB residues predicted to interfere with water passage based on steered Molecular Dynamics are key to germinosome stability

L. Chen, H. Beekhuis, C. v. d. Bosch, G. Vinay, G. Korza, J. Vreede, P. Setlow, S. Brul

The paper identifies three key residues in GerAB that affect water passage and germinosome stability through mutagenesis and molecular dynamics simulations.

bioRxiv · Jun 28, 2024 · PreprintMicrobiology

Non-mechanical disruption of Bacillus subtilis spores allows sensitive and deep characterization of the minimal proteome for resuming a cellular lifestyle.

Y. Huang, A. de Koster, Z. Tu, X. Gao, W. Roseboom, S. Brul, P. Setlow, G. Kramer

This paper introduces a new sample preparation method, SPEED, which improves proteomic analysis of Bacillus subtilis spores by identifying more proteins and enabling differentiation between spore and vegetative cell proteins.

bioRxiv · Mar 8, 2024 · PreprintMicrobiology

Integrative metabolomics and proteomics allow the global intracellular characterization of Bacillus subtilis cells and spores.

Y. Huang, B. N. Swarge, W. Roseboom, J. D. Bleeker, S. Brul, P. Setlow, G. Kramer

This study uses metabolomics and proteomics to characterize B. subtilis vegetative cells and spores, showing differences between them and demonstrating the effectiveness of the 60% EtOH extraction protocol.

bioRxiv · Jun 19, 2023Microbiology

Visualization of SpoVAEa protein dynamics in dormant spores of Bacillus cereus and dynamic changes in their germinosomes and SpoVAEa during germination

Y. Wang, N. O. E. Vischer, D. Wekking, A. Bogian, P. Setlow, S. BRUL

This study investigates the dynamics of SpoVAEa protein movement and germinosome formation in B. cereus spores during germination, revealing heterogeneous behavior and persistence of protein complexes beyond germination initiation.

bioRxiv · Jan 10, 2022Microbiology

Organization and dynamics of the SpoVAEa protein, and its surrounding inner membrane lipids upon germination of Bacillus subtilis spores

J. Wen, N. O. E. Vischer, A. L. de Vos, E. M. M. Manders, P. Setlow, S. Brul

The paper tracks the dynamics of SpoVAEa and its surrounding inner membrane during Bacillus subtilis spore germination, showing a functional microdomain that disappears with germination.

bioRxiv · Nov 20, 2021Microbiology

Heat activation and inactivation of bacterial spores. Is there an overlap?

J. Wen, J. P. P. M. Smelt, N. O. E. Vischer, A. L. d. Vos, P. Setlow, S. Brul

This paper investigates heat activation and inactivation of Bacillus subtilis spores, finding that specific temperatures promote germination while others cause damage.

bioRxiv · Nov 20, 2021Microbiology

High resolution analysis of proteome dynamics during Bacillus subtilis sporulation

Z. Tu, H. Dekker, W. Roseboom, B. Swarge, P. Setlow, S. Brul, G. Kramer

This study uses high-resolution time-lapse proteomics to analyze proteome dynamics during Bacillus subtilis sporulation, identifying co-expressed modules and potential new sporulation-related proteins.

bioRxiv · May 20, 2021Microbiology