S. Brul

Environmentally mediated interactions predict community assembly and invasion success in a gut microbiota SynCom

This study uses a synthetic gut microbiota community to predict invasion success and community stability by modeling interactions between species.

De novo acquisition of antibiotic resistance in six species of bacteria

This study investigates de novo antibiotic resistance acquisition in six bacterial species, finding diverse mutational patterns leading to similar resistance outcomes.

GerAB residues predicted to interfere with water passage based on steered Molecular Dynamics are key to germinosome stability

The paper identifies three key residues in GerAB that affect water passage and germinosome stability through mutagenesis and molecular dynamics simulations.

Non-mechanical disruption of Bacillus subtilis spores allows sensitive and deep characterization of the minimal proteome for resuming a cellular lifestyle.

This paper introduces a new sample preparation method, SPEED, which improves proteomic analysis of Bacillus subtilis spores by identifying more proteins and enabling differentiation between spore and vegetative cell proteins.

Isolation and characterization of persisters of the pathogenic microorganism Staphylococcus aureus

This study isolates and characterizes persisters of Staphylococcus aureus induced by vancomycin and enrofloxacin, revealing molecular and metabolic differences and factors affecting their formation.

Reactive oxygen species accelerate de novo acquisition of antibiotic resistance in E. coli

This study shows that reactive oxygen species from sublethal antibiotics promote de novo resistance in E. coli by increasing DNA damage and mutation rates.

Multi-omics analysis of Bacillus. subtilis spores formed at different environmental temperatures reveal differences at the morphological and molecular level.

This study analyzes B. subtilis spores formed at different temperatures to identify molecular and morphological differences.

Molecular physiological characterization of the dynamics of persister formation in Staphylococcus aureus.

This study investigates the molecular dynamics of persister formation in Staphylococcus aureus under vancomycin and enrofloxacin exposure, revealing stress-specific molecular profiles and the potential of combined therapies.

Integrative metabolomics and proteomics allow the global intracellular characterization of Bacillus subtilis cells and spores.

This study uses metabolomics and proteomics to characterize B. subtilis vegetative cells and spores, showing differences between them and demonstrating the effectiveness of the 60% EtOH extraction protocol.

Exploring the potential of Bacillus subtilis as cell factory for food ingredients and special chemicals

This study compares different Bacillus subtilis strains for their growth and metabolic potential in industrial applications, identifying strains suitable for producing food ingredients and special chemicals.

Model-driven approach for the production of butyrate from CO2/H2 by a novel co-culture of C. autoethanogenum and C. beijerinckii.

The paper designs a co-culture of Clostridium autoethanogenum and C. beijerinckii to produce butyrate from CO2/H2 using metabolic modeling and experimental validation.

Visualization of SpoVAEa protein dynamics in dormant spores of Bacillus cereus and dynamic changes in their germinosomes and SpoVAEa during germination

This study investigates the dynamics of SpoVAEa protein movement and germinosome formation in B. cereus spores during germination, revealing heterogeneous behavior and persistence of protein complexes beyond germination initiation.

Organization and dynamics of the SpoVAEa protein, and its surrounding inner membrane lipids upon germination of Bacillus subtilis spores

The paper tracks the dynamics of SpoVAEa and its surrounding inner membrane during Bacillus subtilis spore germination, showing a functional microdomain that disappears with germination.

Heat activation and inactivation of bacterial spores. Is there an overlap?

This paper investigates heat activation and inactivation of Bacillus subtilis spores, finding that specific temperatures promote germination while others cause damage.

The role of the gut microbiota in the effects of early-life stress and dietary fatty acids on later-life central and metabolic outcomes in mice

This study investigates how early-life stress and dietary fatty acids affect gut microbiota composition and its relationship to later-life cognitive, metabolic, and fatty acid outcomes in mice.

High resolution analysis of proteome dynamics during Bacillus subtilis sporulation

This study uses high-resolution time-lapse proteomics to analyze proteome dynamics during Bacillus subtilis sporulation, identifying co-expressed modules and potential new sporulation-related proteins.

Discovery of potent inhibitors of PLproCoV2 by screening libraries of selenium-containing compounds

The paper screens selenium-containing compounds to identify potent inhibitors of SARS-CoV-2 PLpro, finding four nanomolar-range inhibitors.

Ebselen as a highly active inhibitor of PLProCoV2

This paper identifies ebselen as a potent inhibitor of SARS-CoV-2 PLPro, showing low micromolar potency and structural differences from SARS-CoV-1 PLPro.

Vegetative Cell and Spore Proteomes of Clostridioides difficile show finite differences and reveal potential biomarkers.

The paper compares the proteomes of vegetative cells and spores of Clostridioides difficile to identify potential biomarkers for infection.

Investigating the influence of spore maturation and sporulation conditions on MalS expression during Bacillus subtilis spore germination.

The paper examines MalS-GFP fluorescence dynamics during B. subtilis spore germination and finds initial fluorescence increase followed by stabilization, with Western blot showing no protein level increase in the first 15 minutes.

Integrative analysis of proteome and transcriptome dynamics during Bacillus subtilis spore revival

This study analyzes transcriptome and proteome changes during Bacillus subtilis spore germination and outgrowth, identifying key transcripts and proteins involved in the process.

Towards the minimal proteome of life: Proteome profiles of Bacillus subtilis vegetative cells and spores

This study quantifies protein levels in Bacillus subtilis vegetative cells and spores using 15N metabolic labeling, revealing 60% shared proteins essential for spore survival and germination.