Author

P. Verginis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell-cell communication· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

A. Hatzioannou· 2 shared I. Mitroulis· 2 shared L. Boon· 2 shared M. Grigoriou· 2 shared T. Alissafi· 2 shared A. Banos· 1 shared A. Boumpas· 1 shared A. Delis· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCancer Biology

A. Hatzioannou

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

An Immunological Synapse Formation Between T Regulatory Cells and Cancer-Associated Fibroblasts Promotes Tumor Development

A. Varveri, M. Papadopoulou, Z. Papadovasilakis, E. B. Compeer, A. I. Legaki, A. Delis, V. Damaskou, L. Boon, S. Papadogiorgaki, M. Samiotaki, P. G. Foukas, A. Hatzioannou, T. Alissafi, M. L. Dustin, P. Verginis

This study identifies an immunosuppressive mechanism in the tumor microenvironment where SMA+ cancer-associated fibroblasts process and present tumor antigens via autophagy to form immunological synapses with Foxp3+ T regulatory cells, promoting tumor development.

bioRxiv · Dec 22, 2023 · PreprintCancer Biology

PD-L1 blockade immunotherapy rewires cancer emergency myelopoiesis

A. Boumpas, A. S. Papaioannou, P. Bousounis, M. Grigoriou, V. Bergo, I. Papafragkos, A. Tasis, M. Iskas, L. Boon, M. Makridakis, A. Vlahou, E. Gavriilaki, A. Hatzioannou, I. Mitroulis, E. Trompouki, P. Verginis

This study shows PD-L1 blockade in tumor-bearing mice targets bone marrow HSPCs, reprograms their transcriptome toward inflammation, and reduces myeloid-derived suppressor cells.

bioRxiv · Dec 20, 2023 · PreprintImmunology

Patrolling human SLE haematopoietic progenitors demonstrate enhanced extramedullary colonisation; implications for peripheral tissue injury

I. Kokkinopoulos, A. Banos, M. Grigoriou, A. Filia, T. Manolakou, T. Alissafi, N. Malissovas, I. Mitroulis, P. Verginis, D. T. Boumpas

The paper compares gene transcription signatures of HSPCs from bone marrow and blood in healthy and SLE individuals, finding distinct patterns and enhanced extramedullary colonisation in SLE HSPCs.

bioRxiv · Jan 15, 2021Cell Biology