Hookworm-derived small molecule extracts suppress pathology in a mouse model of colitis and inhibit secretion of key inflammatory cytokines in primary human leukocytes
P. Wangchuk, C. Constantinoiu, K. A. Kouremenos, L. Becker, L. Jones, C. Shepherd, G. Buitrago, P. Giacomin, N. L. Daly, M. J. McConville, R. Ryan, J. Miles, A. Loukas
This study identifies anti-inflammatory small molecules from hookworms that reduce colitis pathology in mice and inhibit cytokine secretion in human leukocytes.
Infection and Immunity · Apr 1, 2019Peer-reviewedMicrobiology