Author

A. Loukas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 9 Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 10 Assay:proteomics· 7 Research Focus:host-pathogen & immune response· 6 Organism:human· 6 Research Focus:cell type annotation· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

J. Sotillo· 7 shared L. Becker· 4 shared P. Giacomin· 3 shared P. J. Brindley· 3 shared S. Chaiyadet· 3 shared T. Laha· 3 shared B. A. Tedla· 2 shared C. Constantinoiu· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

7 shared papersMicrobiology

J. Sotillo

Mutual co-authors in cluster

Author profile →

12 papers

Recent·Most cited

Tetraspanins from Opisthorchis viverrini stimulate cholangiocyte migration and inflammatory cytokine production.

A. Ruangsuwast, M. J. Smout, P. J. Brindley, A. Loukas, T. Laha, S. Chaiyadet

This study shows that O. viverrini tetraspanins enhance cholangiocyte proliferation, cytokine production, and migration, contributing to a cancerous microenvironment.

bioRxiv · Jun 12, 2023 · PreprintCell Biology

Small extracellular vesicles but not microvesicles from Opisthorchis viverrini promote cell proliferation in human cholangiocytes.

S. Chaiyadet, J. Sotillo, M. Smout, M. Cooper, D. Doolan, A. Waardenberg, R. Eichenberger, M. A. Field, T. Laha, A. Loukas

This study identifies that specific extracellular vesicles from Opisthorchis viverrini promote human cholangiocyte proliferation, suggesting a role in cholangiocarcinoma development.

bioRxiv · May 22, 2023 · PreprintMicrobiology

Differential excretory/secretory proteome of the adult female and male stages of the human blood fluke, Schistosoma mansoni

E. T. Kenney, V. H. Mann, W. I. Tanno, B. A. Rosa, M. Mitreva, B. K. Bracken, A. Loukas, P. J. Brindley, J. Sotillo

The paper identifies and compares excretory/secretory proteins from adult male and female Schistosoma mansoni worms using proteomics, revealing sex-specific functional differences.

bioRxiv · May 22, 2022Microbiology

Knockout of liver fluke granulin, Ov-grn-1, impedes malignant transformation during chronic infection with Opisthorchis viverrini

S. Chaiyadet, S. Tangkawattana, M. J. Smout, W. Ittiprasert, V. H. Mann, R. Deenonpoe, P. Arunsan, A. Loukas, P. J. Brindley, T. Laha

This study shows that knocking out the liver fluke gene Ov-grn-1 reduces malignant transformation in a hamster model of opisthorchiasis-associated cholangiocarcinoma.

bioRxiv · Dec 10, 2021Cancer Biology

Schistosoma haematobium extracellular vesicle proteins confer protection in a heterologous model of schistosomiasis

G. G. Mekonnen, B. A. Tedla, D. Pickering, L. Becker, L. Wang, B. Zhan, M. E. Bottazzi, A. Loukas, J. Sotillo, M. S. Pearson

The paper identifies extracellular vesicle proteins from Schistosoma haematobium and shows that vaccinating mice with recombinant tetraspanins reduces egg burdens in a heterologous schistosomiasis model.

Vaccines · Jul 24, 2020Peer-reviewedMicrobiology

Vaccination with Schistosoma mansoni cholinesterases reduces parasite burden and egg viability in a mouse model of schistosomiasis

M. Pearson, B. A. Tedla, D. Pickering, L. Becker, A. Loukas

This study shows that vaccinating mice with Schistosoma mansoni cholinesterases reduces parasite burden and egg viability, suggesting their potential as vaccine targets for schistosomiasis.

bioRxiv · Jan 28, 2020Microbiology

Inflammasome-independent role for NLRP3 in controlling innate anti-helminth immunity and tissue repair in the lung

A. Chenery, R. Alhallaf, Z. Agha, J. Ajendra, J. Parkinson, M. M. Cooper, B. H. Chan, R. M. Eichenberger, L. A. Dent, A. A. Robertson, A. Kupz, D. Brough, A. Loukas, T. E. Sutherland, J. E. Allen, P. Giacomin

This study shows NLRP3 limits lung neutrophilia and helminth killing in an inflammasome-independent way, while promoting tissue repair.

bioRxiv · Jun 7, 2019Immunology

Hookworm-derived small molecule extracts suppress pathology in a mouse model of colitis and inhibit secretion of key inflammatory cytokines in primary human leukocytes

P. Wangchuk, C. Constantinoiu, K. A. Kouremenos, L. Becker, L. Jones, C. Shepherd, G. Buitrago, P. Giacomin, N. L. Daly, M. J. McConville, R. Ryan, J. Miles, A. Loukas

This study identifies anti-inflammatory small molecules from hookworms that reduce colitis pathology in mice and inhibit cytokine secretion in human leukocytes.

Infection and Immunity · Apr 1, 2019Peer-reviewedMicrobiology

In-depth proteomic characterization of Schistosoma haematobium: towards the development of new tools for elimination

J. Sotillo, M. S. Pearson, L. Becker, G. G. Mekonnen, A. Amoah, G. van Dam, P. L. A. M. Corstjens, T. Mduluza, F. Mutapi, A. Loukas

This study characterizes the proteomes of Schistosoma haematobium and identifies potential diagnostic markers for infection intensity.

bioRxiv · Dec 10, 2018Microbiology

Comprehensive analysis of human hookworm secreted proteins using a proteogenomic approach

J. Logan, S. S. Manda, Y.-J. Choi, M. Field, R. Eichenberger, J. Mulvenna, S. Nagaraj, R. Fujiwara, P. Gazzinelli-Guimaraes, L. Bueno, V. Mati, M. Mitreva, J. Sotillo, A. Loukas

This study characterizes the excretory/secretory proteome of the human hookworm Necator americanus using proteogenomic analysis, improving genome annotation and identifying potential vaccine and drug targets.

bioRxiv · Sep 3, 2018 · PreprintMicrobiology

Characterisation Of Trichuris muris Secreted Proteins And Extracellular Vesicles Provides New Insights Into Host-Parasite Communication

R. M. Eichenberger, M. H. Talukder, M. Field, P. Wangchuk, P. Giacomin, A. Loukas, J. Sotillo

This study characterizes secreted proteins and extracellular vesicles from Trichuris muris, identifying their proteomic and genomic content and demonstrating their interaction with host cells.

bioRxiv · Dec 14, 2017Microbiology

Revisiting The Ancylostoma caninum Secretome Provides New Information On Hookworm-Host Interactions

T. Morante, C. Shepherd, C. Constantinoiu, A. Loukas, J. Sotillo

This study reanalyzes the secretome of Ancylostoma caninum using advanced techniques, identifying 315 proteins and highlighting potential vaccine candidates and immunomodulatory proteins.

bioRxiv · May 17, 2017Microbiology