BioengineeringComputational and Structural Biotechnology JournalPeer-reviewed
Enhancing viscosity control in antibody formulations: A framework for the biophysical screening of mutations targeting solvent-accessible hydrophobic and electrostatic patches
Georgina Bethany Armstrong, Vidhi Shah, Paula Sanches…·Zahra Rattray
This study presents a framework for computationally screening mutations to modify antibody viscosity, showing that hydrophobic and electrostatic patches significantly affect viscosity, with positive charges causing the most increase.
19 citations