BiochemistryJACS AuPeer-reviewed
Changes in Active Site Loop Conformation Relate to the Transition toward a Novel Enzymatic Activity
Pauline Jacquet, Raphaël Billot, Amir Shimon…·Mikael H. Elias
The paper redesigns the active site of lactonase SsoPox to enhance phosphotriester catalytic activity, revealing that loop conformation changes are critical for activity shifts.
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