1,3- and 1,4-linked Polysaccharides Uptake in Intestinal Cells Relies on Clathrin/Dynamin 1/Rab5-dependent Endocytosis
Wenfeng Liao, Dianxiu Cao, Ying Wang, Zhenyun Du, Yao Jx, Pengfei Dou, Yuandong Zheng, Zhiming Wang, Xia Chen, Peipei Wang, Chungwah Ma, Hao Chen, Xingxing Diao, Kaiping Wang, Kan Ding
Orally administered β-1,3- and α-1,4-linked polysaccharides cross intestinal epithelium into rodent plasma and liver as macromolecules via clathrin-, dynamin 1-, and Rab5-dependent endocytosis mediated by EGFR, Dectin-1, and BMPRIA.
Nature Communications · Jan 26, 2026Peer-reviewedPharmacology & Toxicology✦ In-depth digest