Hippocampal Glucuronyl C5-epimerase promotes stress resilience by directly engaging PI3K through a non-enzymatic mechanism
Meilin Chen, Lulin Huang, Songyu Yao, Jie Li, Fei He, Muya Xiong, Jianping Fang, Yanling Li, Yu Zhang, Wenfeng Liao, Zhenyun Du, Fei Guo, Tianyu Li, Jinjin Duan, Jing Nie, , Kan Ding
This study identifies Glce as a non-enzymatic regulator of hippocampal dendritic integrity and stress resilience through direct activation of PI3K, revealing a novel mechanism in depression pathophysiology.
bioRxiv · May 6, 2026 · PreprintNeuroscience