ImmunologybioRxiv
Identification and Structural Characterization of a mutant KRAS-G12V specific TCR restricted by HLA-A3
Malcolm J. W. Sim, Ken‐ichi Hanada, Zachary Stotz…·Peter D. Sun
The paper identifies a TCR specific to KRAS-G12V neoantigen and characterizes its structural interaction with HLA-A3, revealing challenges in targeting this mutation.
DOI 10.1002/eji.202451079