Author
National Institutes of Health
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
6 papers
Recent·Most cited
Zhuwei Xu, Hemant Kumar Prajapati, Christopher T Coey…·David J. Clark
The paper uses long-read sequencing to analyze DNA methylation patterns in SDHx-deficient PPGLs and finds global hypomethylation with focal hypermethylation at specific CpG islands.
Kenneth Wu, Zhuwei Xu, Hemant Kumar Prajapati…·David J. Clark
The paper shows Sir proteins impede but do not prevent access to silent chromatin in yeast, using DNA methylation rates as a measure.
Zhuwei Xu, Hemant Kumar Prajapati, Peter R. Eriksson, David J. Clark
The paper assesses the roles of ISW1 and CHD1 chromatin remodelers in suppressing nucleosome dynamics in living yeast cells, finding that their depletion increases DNA methylation rates.
Hemant Kumar Prajapati, Zhuwei Xu, Peter R. Eriksson, David J. Clark
The paper measures genome accessibility in living human cells and finds that heterochromatin is more accessible than previously thought due to dynamic nucleosome behavior.
Peter R. Eriksson, David J. Clark
This study shows that the ISW1b complex is essential for nucleosome spacing and resolving dinucleosomes, while ISW1a has a minor role, and Set2-mediated H3-K36 methylation supports ISW1b function.
Răzvan V. Chereji, Peter R. Eriksson, Josefina Ocampo…·David J. Clark
The paper challenges the idea that DNA accessibility is the main factor in gene regulation by showing that accessibility varies between cells and does not strongly correlate with gene activity.