A bispecific antibody-drug conjugate targeting pCAD and CDH17 has antitumor activity and improved tumor specificity
A. Synan, N. C. Wu, R. Velazquez, C. Logel, K. Mueller, A. Green, P. Barzaghi-Rinaudo, Q. Simmons, S. Mercan, X. Shi, J. Korn, M. McLaughlin, W. R. Tschantz, D. Hainzl, A. Malamas, , J. A. D'Alessio
This study develops a bispecific antibody-drug conjugate targeting pCAD and CDH17, showing antitumor activity in dual antigen-expressing tumors but not in single antigen-expressing tumors.
bioRxiv · Apr 19, 2024Cancer Biology