M. McLaughlin

A bispecific antibody-drug conjugate targeting pCAD and CDH17 has antitumor activity and improved tumor specificity

This study develops a bispecific antibody-drug conjugate targeting pCAD and CDH17, showing antitumor activity in dual antigen-expressing tumors but not in single antigen-expressing tumors.

Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T cell receptor signalling.

This study shows that combining oncolytic Maraba virus with PD-1 blockade overcomes resistance in advanced melanoma with a cold tumor microenvironment.

PARP inhibitors enhance reovirus-mediated cell killing through the death-inducing signaling complex (DISC) with an associated NF-kappa B-regulated immune response.

This paper identifies PARP inhibitors as sensitizers for oncolytic reovirus by enhancing DISC-mediated apoptosis and NF-kappa B-driven immune responses.

Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent anti-PD-L1- and anti-NKG2A-based adjuvant immunotherapy

This study combines ATR inhibition with radiotherapy and immune checkpoint blockade to enhance antitumour immunity in HNSCC preclinical models.

XRE Transcription Factors Conserved in Caulobacter and {varphi}CbK Modulate Adhesin Development and Phage Production

This study identifies XRE transcription factors in Caulobacter and its phage {varphi}CbK that regulate adhesin development and phage production through heteromeric interactions and gene repression.

The Caulobacter NtrB-NtrC two-component system bridges nitrogen assimilation and cell development

This study investigates the role of the NtrB-NtrC two-component system in Caulobacter nitrogen metabolism and development, revealing its impact on growth, cell cycle regulation, and polysaccharide synthesis.

Prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies

The paper examines immune responses in vaccinated individuals during SARS-CoV-2 breakthrough infection, showing early activation of memory T cells and subsequent neutralizing antibody production.

CDK4/6 inhibition and dsRNA sensor agonism co-operate to enhance anti-cancer effects through ER stress and immune modulation of tumour cells

A cryptic transcription factor regulates Caulobacter adhesin development

This paper identifies RtrC, a transcription factor regulated by the adhesion TCS system in Caulobacter crescentus, which represses hfiA to activate holdfast development and influences biofilm formation.

Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

This study examines antibody and memory B cell responses after a third dose of SARS-CoV-2 mRNA vaccine, showing improved antibody quality and stable memory B cells capable of recognizing multiple variants.

mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern

This study shows that mRNA vaccination generates durable immune memory against SARS-CoV-2 and variants of concern, with continued evolution of B and T cell responses for at least 6 months.

In-Depth Characterization and Validation in BRG1-Mutant Lung Cancers Define Novel Catalytic Inhibitors of SWI/SNF Chromatin Remodeling

This study validates novel BRM/BRG1 ATPase inhibitors as chemical probes for SWI/SNF chromatin remodeling and shows their therapeutic potential in BRG1-mut lung cancers.

Split personality of Aluminum Activated Malate Transporter family proteins: facilitation of both GABA and malate transport

This study shows that ALMT proteins facilitate both GABA and malate transport, with GABA regulation dependent on a specific motif and affecting malate efflux.