K. Mueller

A bispecific antibody-drug conjugate targeting pCAD and CDH17 has antitumor activity and improved tumor specificity

This study develops a bispecific antibody-drug conjugate targeting pCAD and CDH17, showing antitumor activity in dual antigen-expressing tumors but not in single antigen-expressing tumors.

Production and characterization of virus-free, CRISPR-CAR T cells capable of inducing solid tumor regression

This study produces and tests virus-free CRISPR-CAR T cells that effectively regress solid tumors in vivo.

Sperm migration in the genital tract - in silico experiments identify key factors for reproductive success

This paper develops an in silico model of sperm migration in the female genital tract, identifying key factors like sperm velocity and mucus flow that influence reproductive success.

RASSF1A independence and early Galectin-1 upregulation in PIK3CA induced hepatocarcinogenesis: new therapeutic venues

This study shows that PIK3CA mutations drive hepatocarcinogenesis independently of RASSF1A status, with early Galectin-1 upregulation and synergistic therapeutic effects of PIK3CA and Galectin-1 inhibitors.

Mapping of safe and early chemo-attenuated live Plasmodium falciparum immunization identifies immune signature of vaccine efficacy

This study evaluates the safety and efficacy of chemo-attenuated Plasmodium falciparum immunization, identifying immune signatures that correlate with vaccine protection.

Low immunogenicity of malaria pre-erythrocytic stages can be overcome by vaccination

This study shows that poor immunogenicity of EEF antigens does not prevent their susceptibility to CD8+ T cell killing, challenging the assumption that immunogenicity is a key criterion for vaccine development.

Nano-Emulsion Adjuvant Enhances Cross-presentation by Lipid Body Formation Independent of Glycolysis

This study shows that the nano-emulsion adjuvant Adjuplex enhances cross-presentation in dendritic cells without requiring glycolysis, relying instead on lipid body formation and ROS.

The importance of the immunodominant CD8+ T cell epitope of Plasmodium berghei circumsporozoite protein in parasite- and vaccine-induced protection

This study shows that the SYIPSAEKI epitope of Plasmodium berghei CSP is critical for CD8+ T cell-mediated protection against malaria, but not essential for vaccine-induced immunity in all mouse strains.

Label-free Method for Classification of T cell Activation

This paper develops a label-free method using NAD(P)H and FAD autofluorescence imaging and machine learning to classify T cell activation states and subtypes with high accuracy.