BiochemistrybioRxivPreprint
PAM-interacting domain swapping is extensively utilized in nature to evolve CRISPR-Cas9 nucleases with altered PAM specificities
Q. y. Wang, X. m. Bian, J. l. Du…·T. Xie
The paper identifies domain swapping in Cas9 proteins as a mechanism for evolving PAM specificity, demonstrating its prevalence and utility in generating novel PAM-specific enzymes.
DOI 10.1101/2021.05.01.442224