Author

J. l. Du

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:metabolomics· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. L. Engel· 1 shared A. Ramakrishnan· 1 shared A. Yanagida· 1 shared B. Anand-Apte· 1 shared D. J. Wilson· 1 shared E. Worrall· 1 shared J. B. Hurley· 1 shared J. H. Qi· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

A. L. Engel

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Author profile →

2 papers

Recent·Most cited

PAM-interacting domain swapping is extensively utilized in nature to evolve CRISPR-Cas9 nucleases with altered PAM specificities

Q. y. Wang, X. m. Bian, J. l. Du, Y. w. Lv, L. Tao, T. Xie

The paper identifies domain swapping in Cas9 proteins as a mechanism for evolving PAM specificity, demonstrating its prevalence and utility in generating novel PAM-specific enzymes.

bioRxiv · May 1, 2021 · PreprintBiochemistry

Extracellular Matrix Dysfunction in Sorsby Patient-Derived Retinal Pigment Epithelium

A. L. Engel, Y. Wang, T. Khuu, E. Worrall, M. A. Manson, R. R. Lim, K. Knight, A. Yanagida, J. H. Qi, A. Ramakrishnan, R. G. Weleber, M. Klein, D. J. Wilson, B. Anand-Apte, J. B. Hurley, , J. R. Chao

This study examines SFD patient-derived iPSC-RPE for extracellular matrix dysfunction and oxidative stress, finding increased sub-RPE deposits and elevated 4-hydroxyproline levels.

bioRxiv · Jan 6, 2021Cell Biology