Molecular BiologybioRxivPreprint
Genome-wide DNA supercoiling arises from transcription and SMC activity and mediates transcriptional negative feedback
Linying Zhu, Qian Yao, Charan Vemuri, Chongyi Chen
The paper shows that genome-wide DNA supercoiling in human cells results from transcription and SMC complexes, and mediates transcriptional negative feedback.
DOI 10.64898/2026.03.26.714539