Qiang Wang

A multi-omics resource of B cell activation reveals genetic mechanisms for immune-mediated diseases

This study profiles B cell activation states using multi-omics data to identify genetic mechanisms underlying immune-mediated diseases.

Beyond Navigation - Tissue-contacting Fluorescent Lifetime Imaging reveals a pathology-linked lung cancer phenotype at the point of biopsy

The paper validates a tumour-associated phenotype identified by FLIM in lung cancer biopsies, showing it is reproducible across imaging systems and distinguishable from normal tissue.

Kidney medulla macrophages maintain a free flow of urine by sensing force

This study identifies Piezo1 as a mechanoreceptor in kidney medulla macrophages that enables them to clear sedimentary particles and prevent kidney stones.

Employing the intravesical delivery route to target on the kidney

This study evaluates the efficacy of intravesical delivery for kidney targeting in mice, showing improved therapeutic outcomes and reduced side effects compared to systemic delivery.

Single-cell Characterization of DNA Hydroxymethylation of the Mouse Brain During Aging

The paper introduces Joint-Cabernet, a single-cell platform for profiling 5hmC and 5mC, and applies it to mouse brain nuclei to study DNA hydroxymethylation changes with aging.

Ferroptosis mediates the progression of hyperuricemic nephropathy by activating RAGE signaling

This study shows ferroptosis contributes to hyperuricemic nephropathy by activating RAGE signaling, and inhibiting ferroptosis improves renal injury and fibrosis in a mouse model.