Xinge Wang

This study identifies Piezo1 as a mechanoreceptor in kidney medulla macrophages that enables them to clear sedimentary particles and prevent kidney stones.

The paper investigates gene regulatory networks in alveolar macrophages, finding that tissue-resident macrophages have more restrained inflammatory responses due to a stabilizing network involving PU.1 and CEBP/β.

This study evaluates the efficacy of intravesical delivery for kidney targeting in mice, showing improved therapeutic outcomes and reduced side effects compared to systemic delivery.

SenePy identifies cell-type specific senescence signatures from single-cell data, improving senescent cell detection in vivo and revealing increased senescence in diseases like COVID-19 and myocardial infarction.

This paper develops a CRISPR-based diagnostic platform for SARS-CoV-2 detection with a low detection limit and no cross-reactivity.