Tian Tian

This study identifies ileal Gpbar1 as a peripheral node that regulates depressive behaviors via a gut-to-brain GABAergic axis, showing that agonism of Gpbar1 can reverse depressive-like phenotypes.

STUltra integrates spatial transcriptomics data to map disease traits onto spatiotemporal tissue landscapes, outperforming existing methods in scalability and speed.

This paper shows tirzepatide reduces atherosclerosis independently of weight loss by directly targeting vascular inflammation through the cAMP/PKA/eNOS pathway.

The paper investigates mRNA localization at dendritic spines and finds that specific mRNAs target different subdomains and require microtubule entry and the motor KIF5A.

This study identifies ERF transcription factors as key regulators of AM fungal-induced lateral root development in maize, revealing a tripartite signaling network involving ethylene, flavonoids, and microbial synergies.

The paper introduces Joint-Cabernet, a single-cell platform for profiling 5hmC and 5mC, and applies it to mouse brain nuclei to study DNA hydroxymethylation changes with aging.

This study shows that NRG-1 postconditioning protects against myocardial I/R injury by activating mitophagy through the UCP2/PINK1/LC3B pathway in rats and H9C2 cells.