R. Abe

Neutrophil Extracellular Traps have DNAzyme activity that drives bactericidal potential

The paper identifies G-quadruplex/hemin DNAzyme complexes in NETs as the primary drivers of bactericidal activity through hydroxyl radical production.

Brefeldin A and M-COPA block the export of RTKs from the endoplasmic reticulum via simultaneous inactivation of ARF1, ARF4, and ARF5

This study shows that BFA and M-COPA inhibit RTK export from the ER by inactivating ARF1, ARF4, and ARF5, leading to cancer cell apoptosis.

Rapid molecular phenotypic antimicrobial susceptibility test for Neisseria gonorrhoeae based on propidium monoazide viability PCR

This paper develops a rapid PCR-based method to determine antimicrobial susceptibility of Neisseria gonorrhoeae using propidium monoazide and qPCR, achieving high accuracy in under 30 minutes.

Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in GIST cells

This study identifies the molecular mechanisms by which mutant KIT remains in the Golgi and activates oncogenic signaling in GIST cells.

FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells.

This study shows FLT3-ITD accumulates in the Golgi apparatus in AML cells, activates signaling pathways like STAT5 and AKT/ERK during biosynthetic trafficking, and its tyrosine kinase activity is required for this retention.