Cancer BiologybioRxivPreprint
FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells.
K. Yamawaki, I. Shiina, T. Murata…·Y. Obata
This study shows FLT3-ITD accumulates in the Golgi apparatus in AML cells, activates signaling pathways like STAT5 and AKT/ERK during biosynthetic trafficking, and its tyrosine kinase activity is required for this retention.
DOI 10.1101/2021.01.01.424454