T. Murata

Structural basis of anticancer drug recognition and amino acid transport by LAT1

This study reports six LAT1 structures bound with ligands, revealing substrate recognition and inhibition mechanisms, including the role of JPH203 as an anticancer drug.

Brefeldin A and M-COPA block the export of RTKs from the endoplasmic reticulum via simultaneous inactivation of ARF1, ARF4, and ARF5

This study shows that BFA and M-COPA inhibit RTK export from the ER by inactivating ARF1, ARF4, and ARF5, leading to cancer cell apoptosis.

Direct Observation of Stepping Rotation of V-ATPase Reveals Rigid Coupling between Vo and V1 Motors

The paper observes ATP-driven stepping rotation of V-ATPase mutants using a gold nanoparticle probe, revealing rigid coupling between Vo and V1 motors through distinct pausing positions and step dynamics.

Chemical screen of Arabidopsis zygote and proteomics in tobacco BY-2 cells identify general plant cell division inhibitors

The paper identifies two plant cell division inhibitors through chemical screening in Arabidopsis zygotes and validates their effects in tobacco BY-2 cells and multiple plant species.

Revealing a hidden intermediate of rotatory catalysis with X-ray crystallography and Molecular simulations

The paper identifies a hidden intermediate in ATP-hydrolyzing motors using X-ray crystallography and simulations, revealing the rate-limiting step as ADP interaction release.

Design of complicated all-α protein structures

This study designs complex all-α protein structures using helix-loop-helix motifs and canonical α-helices, achieving atomic accuracy and thermal stability in solution.

Discovery of the fastest myosin, its amino acid sequence, and structural features

The paper identifies CbXI-1 as the fastest myosin with a velocity of 73 m s-1, cloned from Chara braunii, and reports its atomic structure and structural features contributing to high-speed movement.

A triple-negative matrix-producing breast carcinoma is arrested by tumor-targeting Salmonella typhimurium A1-R in a PDOX model

This study evaluates the efficacy of Salmonella typhimurium A1-R in arresting tumor growth in a triple-negative matrix-producing breast carcinoma PDOX model.

FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells.

This study shows FLT3-ITD accumulates in the Golgi apparatus in AML cells, activates signaling pathways like STAT5 and AKT/ERK during biosynthetic trafficking, and its tyrosine kinase activity is required for this retention.

Epstein-Barr virus tegument protein BGLF2 in exosomes released from virus-producer cells assists de novo infection

This study identifies BGLF2, an EBV tegument protein, as being encapsulated in exosomes that enhance viral infection by boosting gene expression and suppressing innate immunity.

Direct evidence of abortive lytic infection-mediated establishment of Epstein-Barr virus latency during B-cell infection

The paper tracks EBV infection in B-cells using fate mapping and RNA-seq, showing abortive lytic infection precedes latency.

Single-cell transcriptome analysis of Physcomitrella leaf cells during reprogramming using microcapillary manipulation

The paper introduces 1cell-DGE, a single-cell RNA-sequencing method using microcapillary manipulation to analyze gene expression in intact moss tissues, identifying differentially expressed genes during leaf cell reprogramming.