T. Nishida

Liver-specific LXR inhibition represses reverse cholesterol transport in cholesterol-fed mice

This study shows that liver-specific LXR inhibition reduces HDL levels and reverse cholesterol transport in cholesterol-fed mice by decreasing LXR-target gene expression.

Brefeldin A and M-COPA block the export of RTKs from the endoplasmic reticulum via simultaneous inactivation of ARF1, ARF4, and ARF5

This study shows that BFA and M-COPA inhibit RTK export from the ER by inactivating ARF1, ARF4, and ARF5, leading to cancer cell apoptosis.

Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in GIST cells

This study identifies the molecular mechanisms by which mutant KIT remains in the Golgi and activates oncogenic signaling in GIST cells.

FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells.

This study shows FLT3-ITD accumulates in the Golgi apparatus in AML cells, activates signaling pathways like STAT5 and AKT/ERK during biosynthetic trafficking, and its tyrosine kinase activity is required for this retention.

Lipooligosaccharide, Vag8, and pertussis toxin of Bordetella pertussis cooperatively cause coughing in mice

The paper develops a mouse model of whooping cough and identifies that LOS, Vag8, and PTx cooperatively cause coughing by modulating TRPV1 and bradykinin levels.

Focusing on human haplotype diversity in numerous individual genomes demonstrates an evolutional feature of each locus

The paper analyzes haplotype diversity across eight human loci to identify evolutionary events like introgression and selection, using sequence data from the 1000 Genomes Project.

2-Cl-C.OXT-A Stimulates Contraction through the Suppression of Phosphodiesterase Activity in Human Induced Pluripotent Stem Cell-derived Cardiac Organoids

This study shows that COA-Cl increases cardiac organoid contraction by suppressing phosphodiesterase activity, independent of S1P1R and A1R.