Author

R. Alert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Bioengineering· 1 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:development & morphogenesis· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Approach:mechanistic / dynamical model· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Kosmrlj· 2 shared D. J. Cohen· 2 shared M. A. Heinrich· 2 shared P. Roca-Cusachs· 2 shared X. Trepat· 2 shared A. E. Wolf· 1 shared A. Imbert· 1 shared A. Shellard· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBioengineering

A. Kosmrlj

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Optogenetic generation of leader cells reveals a force-velocity relation for collective cell migration

L. Rossetti, S. Grosser, J. F. Abenza, L. Valon, P. Roca-Cusachs, R. Alert, X. Trepat

The paper uses optogenetic Rac1 activation to generate leader cells and shows that collective cell migration requires global mechanical organization rather than autonomous leader action.

Nature Physics · Aug 12, 2024Peer-reviewedCell Biology

Frictiotaxis underlies adhesion-independent durotaxis

A. Shellard, K. W. Weissenbruch, P. Hampshire, N. Stillman, C. Dix, R. Thorogate, A. Imbert, G. Charras, R. Alert, R. Mayor

The paper shows cells can migrate towards stiffer substrates without strong adhesions, proposing a new mechanism called frictiotaxis based on friction gradients.

bioRxiv · Jun 1, 2023 · PreprintCell Biology

Stiffness-dependent active wetting enables optimal collective cell durotaxis

M. E. Pallares, I. Pi-Jauma, I. C. Fortunato, V. Grazu, M. Gomez-Gonzalez, P. Roca-Cusachs, J. M. de la Fuente, R. Alert, R. Sunyer, J. Casademunt, X. Trepat

This study shows that cellular clusters migrate optimally on stiffness gradients by balancing active traction, contractility, and surface tension, based on their wetting properties.

bioRxiv · Jul 24, 2022 · PreprintBiophysics

Morphogenesis and cell ordering in confined bacterial biofilms

Q. Zhang, J. Li, J. Nijjer, H. Lu, M. Kothari, R. Alert, T. Cohen, J. Yan

This study investigates how confined environments influence biofilm morphology and cell ordering in Vibrio cholerae using single-cell imaging and biomechanical analysis.

Proceedings of the National Academy of Sciences · Jul 30, 2021Peer-reviewedMicrobiology

Self-assembly of tessellated tissue sheets by growth and collision

M. A. Heinrich, R. Alert, A. E. Wolf, A. Kosmrlj, D. J. Cohen

This study investigates tissue-tissue interactions through collisions and develops a design tool for self-assembling complex tessellations.

bioRxiv · May 6, 2021Bioengineering

Size-dependent patterns of cell proliferation and migration in freely-expanding epithelia

M. A. Heinrich, R. Alert, J. LaChance, T. J. Zajdel, A. Kosmrlj, D. J. Cohen

This study shows that expanding epithelial monolayers exhibit size-dependent patterns of proliferation and migration, with memory effects based on initial tissue size rather than current conditions.

bioRxiv · Feb 28, 2020Cell Biology