Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit.
J. Elliff, A. Biswas, S. Kuppa, P. Roshan, R. Burd, M. Chinnaraj, A. Patterson, J. Mattice, S. Walker, N. Pozzi, E. Antony, B. Bothner, S. S. Origanti
This study identifies key residues in eIF6 and RPL23 that mediate their interaction and shows how mutations in SDS disrupt this interaction, offering a therapeutic target for cancer and SDS.
bioRxiv · Jul 29, 2022Biochemistry