Author

P. Roshan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:proteomics· 1

Frequent Co-Authors

B. Bothner· 2 shared E. Antony· 2 shared J. Mattice· 2 shared S. Kuppa· 2 shared A. Biswas· 1 shared A. Patterson· 1 shared B. Tumala· 1 shared J. Elliff· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

B. Bothner

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2 papers

Recent·Most cited

An Aurora B-RPA signaling axis secures chromosome segregation fidelity

P. Roshan, S. Kuppa, J. Mattice, V. Kaushik, R. Chadda, N. Pokhrel, B. Tumala, B. Bothner, E. Antony, S. Origanti

This study identifies a mitosis-specific regulation of RPA by Aurora B kinase, showing that phosphorylation of RPA70 at Ser-384 is essential for chromosome segregation fidelity and genomic stability.

bioRxiv · Sep 26, 2022 · PreprintBiochemistry

Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit.

J. Elliff, A. Biswas, S. Kuppa, P. Roshan, R. Burd, M. Chinnaraj, A. Patterson, J. Mattice, S. Walker, N. Pozzi, E. Antony, B. Bothner, S. S. Origanti

This study identifies key residues in eIF6 and RPL23 that mediate their interaction and shows how mutations in SDS disrupt this interaction, offering a therapeutic target for cancer and SDS.

bioRxiv · Jul 29, 2022Biochemistry