Author

J. Mattice

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:protein folding & dynamics· 1 Organism:yeast· 1

Frequent Co-Authors

B. Bothner· 5 shared E. Antony· 5 shared N. Pokhrel· 4 shared A. Patterson· 3 shared R. Chadda· 3 shared S. Kuppa· 3 shared J. Deveryshetty· 2 shared P. Roshan· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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5 shared papersBiochemistry

B. Bothner

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5 papers

Recent·Most cited

Homodecameric Rad52 promotes single-position Rad51 nucleation in homologous recombination

J. Deveryshetty, R. Chadda, J. Mattice, S. Karunakaran, M. Rau, K. Basore, N. Pokhrel, N. Englander, J. Fitzpatrick, B. Bothner, E. Antony

This study reveals that homodecameric Rad52 facilitates single-position Rad51 nucleation in homologous recombination through specific structural and interaction features.

bioRxiv · Feb 5, 2023 · PreprintBiochemistry

An Aurora B-RPA signaling axis secures chromosome segregation fidelity

P. Roshan, S. Kuppa, J. Mattice, V. Kaushik, R. Chadda, N. Pokhrel, B. Tumala, B. Bothner, E. Antony, S. Origanti

This study identifies a mitosis-specific regulation of RPA by Aurora B kinase, showing that phosphorylation of RPA70 at Ser-384 is essential for chromosome segregation fidelity and genomic stability.

bioRxiv · Sep 26, 2022 · PreprintBiochemistry

Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit.

J. Elliff, A. Biswas, S. Kuppa, P. Roshan, R. Burd, M. Chinnaraj, A. Patterson, J. Mattice, S. Walker, N. Pozzi, E. Antony, B. Bothner, S. S. Origanti

This study identifies key residues in eIF6 and RPL23 that mediate their interaction and shows how mutations in SDS disrupt this interaction, offering a therapeutic target for cancer and SDS.

bioRxiv · Jul 29, 2022Biochemistry

Rtt105 configurationally staples RPA and blocks facilitated exchange and interactions with RPA-interacting proteins

S. Kuppa, J. Deveryshetty, R. Chadda, J. Mattice, N. Pokhrel, V. Kaushik, A. Patterson, N. Dhingra, S. Pangeni, M. K. Sadauskas, S. Shiekh, H. Balci, T. Ha, X. Zhao, B. Bothner, E. Antony

This study shows Rtt105 binds to RPA, staples it, and blocks RIP interactions without ssDNA, while stabilizing RPA-ssDNA filaments with ssDNA.

bioRxiv · Feb 5, 2022 · PreprintBiochemistry

Hydrogen-deuterium exchange reveals a dynamic DNA binding map of Replication Protein A

F. Ahmed, A. Patterson, J. Devershetty, J. Mattice, N. Pokhrel, B. Bothner, E. Antony

This study uses HDX-MS to analyze the dynamic DNA binding properties of RPA domains, revealing that DBD-C is most involved in stabilizing RPA on ssDNA.

bioRxiv · Sep 4, 2020Biochemistry