R. Bychkov

The Heart's Pacemaker Mimics Brain Cytoarchitecture and Function: Autonomic innervation, a peripheral glial cell web, and a novel S100B expressing interstitial cell type impart structural and functional complexity to the sinoatrial node

This study describes the 3D cytoarchitecture of the sinoatrial node, revealing autonomic innervation, peripheral glial cells, and a novel S100B-expressing interstitial cell type that contribute to its structural and functional complexity.

Synchronized cardiac impulses emerge from multi-scale, heterogeneous local calcium signals within and among cells of heart pacemaker tissue

This study reveals that cardiac action potentials arise from heterogeneous subcellular calcium signals in mouse sinoatrial node tissue, challenging the traditional model of uniform impulse generation.