BiochemistrybioRxiv
Monoubiquitination by the Fanconi Anemia core complex locks FANCI:FANCD2 on DNA in filamentous arrays
W. Tan, S. van Twest, A. Leis…·A. J. Deans
This study shows that monoubiquitination of FANCD2 stabilizes the FANCI:FANCD2 complex on DNA and forms filamentous arrays, revealing a mechanism for DNA repair pathway activation.
DOI 10.7554/elife.54128