R. C. Vignogna

This study uses experimental evolution in yeast to identify compensatory mutations that alleviate the effects of human disease-associated PMM2 mutations.

The paper shows that overdominant mutations limit loss of heterozygosity at linked loci in yeast, leading to varied evolutionary outcomes.

The paper uses evolutionary replay experiments to identify and validate positive genetic interactions involving KEL1 mutations in yeast, showing these interactions are not detected by loss-of-function methods.

This study shows that genome duplication in haploid yeast provides immediate fitness benefits but reduces long-term adaptability.